Endocrine Abstracts

Background and aimAutoimmune thyroiditis (AIT) is one of the most common autoimmune diseases, affecting more than 10% of females and 2% of males in the overall population. Clinical evidence suggests that oral supplementation with myo-inositol (MI) and vitamin D (VD) is useful in the treatment of AIT. MI is a carbocyclic polyol precursor of phosphoinositide synthesis. It is involved in cell signaling and, precisely, as a second messenger regulating the ac...

IntroductionLatent autoimmune diabetes in adults (LADA) is a specific type of diabetes mellitus (DM), the prevalence of which varies from 4% to 14%. Although LADA combines the pathogenetic and clinical features of both type 1 (T1DM) and type 2 diabetes mellitus (T2DM), the latest recommendations of the American Diabetes Association refer it to T1DM (ADA, 2021). Given that this variant of diabetes is also similar to T2DM, the risk of metabolic syndrome (M...

IntroductionObesity is an important medical and social problem of our time, because its prevalence is growing rapidly and affects about 30% of the adult population of the planet. Obesity is characterized by an increase in the expression of cytokines that cause endothelial damage. It is known that prohormone thyroxine (T4) is converted into 5 times more active triiodothyronine (T3) in peripheral organs (such as live...